Impaired Peyer's patch development in BOB.1/OBF.1‐deficient mice
| Autor: | Thomas Wirth, Thomas K. Hoffmann, Cornelia Brunner, Annika C Betzler, Katja Fiedler, Enikö Kokai |
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| Rok vydání: | 2021 |
| Předmět: |
Receptors
CXCR5 0301 basic medicine Organogenesis Immunology Biology Mice Peyer's Patches 03 medical and health sciences 0302 clinical medicine Transcription (biology) medicine Animals Immunology and Allergy Lymphocyte homing receptor Gene B-Lymphocytes Follicular dendritic cells Peyer's patch Chemokine CXCL13 Embryonic stem cell Cell biology 030104 developmental biology Lymphatic system medicine.anatomical_structure Trans-Activators Dendritic Cells Follicular 030215 immunology |
| Zdroj: | European Journal of Immunology. 51:1860-1863 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.202048578 |
| Popis: | BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13-CXCR5 signaling of LTinducer and LTorganizer cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocyte homing at postnatal stages of secondary lymphoid organ development. |
| Databáze: | OpenAIRE |
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