Raloxifene slows down the progression of intima-media thickness in postmenopausal women
| Autor: | Alessandro Arciello, Federico Cacciapuoti, Luigi Cobellis, Elena Sepe, Felice Fornaro, Daniela Manzella, Marco Torella, Nicola Colacurci, Giuseppe Paolisso, Pasquale De Franciscis |
|---|---|
| Přispěvatelé: | Colacurci, Nicola, Fornaro, F, Cobellis, Luigi, DE FRANCISCIS, Pasquale, Torella, Marco, Sepe, E, Arciello, A, Cacciapuoti, Federico, Paolisso, Giuseppe, Manzella, D. |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Osteoporosis Lower risk Placebo Insulin resistance Internal medicine medicine Humans Raloxifene Osteoporosis Postmenopausal Aged Proportional Hazards Models Ultrasonography Bone Density Conservation Agents Adiponectin business.industry Estrogen Antagonists Obstetrics and Gynecology Middle Aged Atherosclerosis medicine.disease Postmenopause Treatment Outcome Endocrinology Intima-media thickness Raloxifene Hydrochloride Homeostatic model assessment Women's Health Female Tunica Intima Tunica Media business Follow-Up Studies medicine.drug |
| Zdroj: | Menopause. 14:879-884 |
| ISSN: | 1072-3714 |
| DOI: | 10.1097/gme.0b013e3180577893 |
| Popis: | Objective: To investigate the effect of raloxifene on atherosclerosis progression in healthy postmenopausal women. Design: In a prospective fashion, a total of 155 healthy postmenopausal women were randomly assigned to receive raloxifene 60 mg/day or a matching placebo for 18 months. Atherosclerosis progression was evaluated by B-mode ultrasonography measuring the intima-media thickness (IMT) of the carotid arteries. Plasma levels of triglycerides, low-density lipoprotein cholesterol, soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, E-selectin, interleukin-6, tumor necrosis factor a, adiponectin, and the degree of insulin resistance by the homeostatic model assessment method were also determined. Results: The progression slope of carotid IMT was 0.0112 mm/18 months in the raloxifene group and 0.0857 mm/18 months in the placebo group (P < 0.004). Raloxifene treatment compared with placebo produced a significant decrease in plasma triglycerides (P < 0.02), low-density lipoprotein cholesterol (P < 0.02), soluble forms of intercellular adhesion molecule-1(P < 0.005) and vascular cell adhesion molecule-1 (P < 0.04), E-selectin (P < 0.02), interleukin-6 (P < 0.005), tumor necrosis factor a (P < 0.005) levels, and homeostatic model assessment index (P < 0.005) and a significant increase in plasma adiponectin levels (P < 0.001). Logistic regression analysis indicated that women receiving raloxifene had a lower risk of IMT progression (odds ratio = 0.41; 95% CI: 0.32-0.70). Conclusion: Raloxifene treatment, possibly through an increase in plasma adiponectin levels, may slow the progression of IMT in postmenopausal women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|