Defective neutrophil function in low-birth-weight, premature infants
| Autor: | H Al-Hadithy, A H Goldstone, I E Addison, J C Cawley, J C Shaw |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Aging Neutrophils Phagocytosis Cell Physiology Biology Defective neutrophil function Pathology and Forensic Medicine Cell Movement medicine Humans Candida Infant Newborn General Medicine Cell movement Infant Low Birth Weight Infant newborn Low birth weight medicine.anatomical_structure Immunology Hemoglobinometry NEUTROPHIL MIGRATION medicine.symptom Infant Premature Research Article |
| Zdroj: | Journal of Clinical Pathology. 34:366-370 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.34.4.366 |
| Popis: | A whole-blood technique was used to measure simultaneously neutrophil migration, uptake, and killing of candida in 27 premature infants of low birth weight (less than 1500 g). Neutrophil migration was consistently reduced, especially in the first two weeks of life. Phagocytosis was also reduced, particularly in the first week of life and in sick patients. Killing was usually normal, except in sick patients. The three functions were not altered when the test was performed in normal adult, rather than autologous, plasma, and the reduced migration and uptake are therefore the result of an intrinsic defect of the cell. The results clarify the previous controversy concerning neutrophil function in premature infants and provide an explanation for their increased susceptibility to infection. |
| Databáze: | OpenAIRE |
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