Diagnostic performance of 2D-shear wave elastography in the diagnosis of breast cancer: a clinical appraisal of cutoff values
| Autor: | Tommaso Vincenzo Bartolotta, Alessia Angela Maria Orlando, Mariangela Dimarco, Calogero Zarcaro, Fabiola Ferraro, Alessandra Cirino, Domenica Matranga, Salvatore Vieni, Daniela Cabibi |
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| Přispěvatelé: | Bartolotta, Tommaso Vincenzo, Orlando, Alessia Angela Maria, Dimarco, Mariangela, Zarcaro, Calogero, Ferraro, Fabiola, Cirino, Alessandra, Matranga, Domenica, Vieni, Salvatore, Cabibi, Daniela |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Aged 80 and over Reproducibility of Results Breast Neoplasms General Medicine Middle Aged Sensitivity and Specificity Diagnosis Differential Young Adult Elasticity imaging techniques Shear wave imaging Humans Female Radiology Nuclear Medicine and imaging Ultrasonography Mammary Breast Settore MED/36 - Diagnostica Per Immagini E Radioterapia Aged Ultrasonography |
| Popis: | Purpose To assess the role of 2D-shear wave elastography (2D-SWE) in differentiating benign from malignant focal breast lesions (FBLs), providing new vendor-specific cutoff values. Methods 158 FBLs (size: 3.5-50 mm) detected in 151 women (age: 21-87 years) were prospectively evaluated by means 2D-SWE. For each lesion, an expert radiologist assessed US BI-RADS category and calculated the following four 2D-SWE parameters: (1) elasticity maximum (E-max); (2) mean elasticity (E-mean); (3) minimum elasticity (E-min); (4) elasticity ratio (E-ratio). US-guided core-biopsy was considered as standard of reference for all the FBLs classified as BI-RADS 4 or 5. For each 2D-SWE parameter, the optimal cutoff value for a diagnostic test was calculated using the Youden method. Diagnostic performance of the US BI-RADS and 2D-SWE parameters was calculated accordingly. Results 83/158 (52.5%) FBLs were benign and 75/158 (47.5%) were malignant. Statistically significant higher stiffness values were observed in malignant FBLs for all 2D-SWE parameters than in benign ones (p < 0.001). 2D-SWE cutoff values were 82.6 kPa, 66.0 kPa and 53.6 kPa, respectively, for E-max, E-mean, E-min and 330.8% for E-ratio. The 2D-SWE parameter showing the best diagnostic accuracy was E-max (85.44%). Considering US BI-RADS 3 (n = 60) and 4a (n = 32) FBLs, E-max and E-mean showed the best diagnostic accuracy (85.87% for both), without a statistically significant decrease in sensitivity (p = 0.7003 and p = 1, respectively). Conclusion Our study provides new vendor-specific cutoff values for 2D-SWE, suggesting its possible clinical use in the adjunctive assessment of category US-BI-RADS 3 and 4a breast masses. |
| Databáze: | OpenAIRE |
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