LimulusAntilipopolysaccharide Factor Prevents Mortality Late in the Course of Endotoxemia
| Autor: | Alice Child, Robert I. Roth, Jack Levin, Norman R. Wainwright, Donghui Su |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Lipopolysaccharides
Invertebrate Hormones Lipopolysaccharide Ratón Pharmacology Median lethal dose Arthropod Proteins Mice chemistry.chemical_compound Anti-Infective Agents Animals Immunology and Allergy Escherichia coli Infections biology Biological activity Plasma levels biology.organism_classification Enterobacteriaceae Endotoxemia Disease Models Animal Infectious Diseases chemistry Limulus Plasma concentration Immunology Female lipids (amino acids peptides and proteins) Antimicrobial Cationic Peptides |
| Zdroj: | The Journal of Infectious Diseases. 177:388-394 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Limulus antilipopolysaccharide factor (LALF) can neutralize bacterial endotoxin, but its ability to prevent mortality following prolonged endotoxemia is unknown. Mice were challenged with an LD 50 dose of intraperitoneal E. coli lipopolysaccharide (LPS) and then received LALF at various times after administration of LPS. Survival at 72 h was significantly improved by the administration of LALF at 4, 10, and even 24 h after LPS (73%, 78%, and 65% survival, respectively, vs. 15% survival in controls). Following intravenous administration of LALF at either 10 or 24 h after LPS, plasma levels of biologically active LPS abruptly fell (>1000-fold lower than pre-LALF levels). Plasma LALF concentrations fell much more gradually in LPS-treated mice (t 1 /2 = 120 min) than in control mice (t 1 /2 = 2.5 min). In conclusion, LALF markedly decreased plasma concentrations of biologically active LPS and protected mice from lethality even when LALF was not administered until long after the onset of continuous endotoxemia. |
| Databáze: | OpenAIRE |
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