A Genome-Wide Scan for Carotid Artery Intima-Media Thickness
| Autor: | Willa A. Hsueh, Isabel Bulnes-Enriquez, Huiying Yang, Katherine Yu, Xochitl Jimenez, Yanjie Li, Dai Wang, Kent D. Taylor, Jerome I. Rotter, Tamara Modilevsky, Roxana De La Rosa, Manuel J. Quiñones, Howard N. Hodis |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Arteriosclerosis Genetic Linkage Carotid arteries Coronary Artery Disease Mexican americans Coronary artery disease Quantitative Trait Heritable Internal medicine Mexican Americans medicine Humans Genetic Testing cardiovascular diseases Stroke Subclinical infection Family Health Advanced and Specialized Nursing Genome Human Vascular disease business.industry Chromosome Mapping Heritability medicine.disease Surgery Carotid Arteries Intima-media thickness Cardiology Female Neurology (clinical) Insulin Resistance Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business Biomarkers Microsatellite Repeats |
| Zdroj: | Stroke. 36:540-545 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.0000155746.65185.4e |
| Popis: | Background and Purpose— Carotid artery intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with coronary artery disease (CAD), and stroke. CIMT is also an important predictor of clinical cardiovascular events. To systematically identify the genetic determinants of CIMT, we performed a genome-wide scan using data from 91 2-generation Mexican American families ascertained via a parent with CAD diagnosed. Methods— CIMT was measured in 274 adult offspring (mean age, 34.6 years) using high-resolution B-mode ultrasound; 413 subjects, including adult offspring and their parents, were genotyped using Marshfield screen set 12 (380 microsatellite markers at ≈10-cM interval). Heritability was estimated using the variance component approach implemented in SOLAR. Linkage analyses were performed using both the sib-pair regression approach and the variance component approach. Results— The estimated heritability was 0.68, 0.45, and 0.40 for unadjusted, gender- and age-adjusted, and multivariate-adjusted CIMT, respectively. The strongest evidence of linkage was found on chromosome 2 at D2S2944 (logarithm of the odds [LOD]=3.08). Other suggestive linkages were also found on chromosome 6 at D6S1022 to D6S2410 (LOD=2.21) and chromosome 13 at D13S796 to D13S895 (LOD=1.34). Conclusions— These results show that there is a strong genetic effect on CIMT in these Mexican American CAD families. The linkage peak on chromosome 2 suggests that there is a gene (or genes) at this chromosome location influencing CIMT. |
| Databáze: | OpenAIRE |
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