Interleukin-12 and interleukin-10 production by mononuclear phagocytic cells from breast cancer patients
| Autor: | Sebastiano Gangemi, Adriana Arena, Rosaria Alba Merendino, S. Chillemi, F. Purello D’Ambrosio, A. Misefari, A.B. Capozza |
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| Rok vydání: | 1999 |
| Předmět: |
business.industry
Monocyte Immunology Carcinoma Ductal Breast Interleukin Breast Neoplasms Mononuclear phagocyte system Middle Aged Peripheral blood mononuclear cell Interleukin-12 Monocytes Interleukin-10 Interleukin 10 medicine.anatomical_structure Immune system Interleukin 15 medicine Interleukin 12 Immunology and Allergy Humans Female skin and connective tissue diseases business Aged |
| Zdroj: | Immunology letters. 68(2-3) |
| ISSN: | 0165-2478 |
| Popis: | Interleukin-10 (IL-10) and Interleukin 12 (IL-12) generation may be regulated by a complex monocyte and macrophage-derived cytokine network and an impairment of the immune system can be observed in neoplastic disease. In this study, we examined the production of these cytokines by phagocytic cells, obtained from breast cancer (BCa)-bearing patients. Our results suggest that an increased IL-10 formation may represent an important regulatory pathway of IL-12 production by BCa mononuclear cells. In this report, we show that mononuclear cells of patients affected by breast cancer have a defective IL-12 production capability while generating higher amounts of IL-10. |
| Databáze: | OpenAIRE |
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