Bisphenols emerging in Norwegian and Czech aquatic environments show transthyretin binding potency and other less-studied endocrine-disrupting activities
| Autor: | Helena Švecová, Vit Kodes, Kateřina Grabicová, Pavel Šauer, Hana Kocour Kroupova, Farah Gönül Aydin, Line Diana Blytt, Tomáš Mackuľak, Roman Grabic, Liv Bruås Henninge |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Bisphenol A Environmental Engineering 010504 meteorology & atmospheric sciences Bisphenol 010501 environmental sciences 01 natural sciences Bisphenol AF chemistry.chemical_compound Phenols Prealbumin Environmental Chemistry Bioassay CALUX Benzhydryl Compounds Waste Management and Disposal reproductive and urinary physiology Czech Republic 0105 earth and related environmental sciences Pollutant Norway urogenital system Pollution chemistry Bisphenol S Environmental chemistry Environmental Pollutants hormones hormone substitutes and hormone antagonists Sludge |
| Zdroj: | Science of The Total Environment. 751:141801 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2020.141801 |
| Popis: | Bisphenols are increasingly recognized as environmental pollutants with endocrine-disrupting potential. Nonetheless, the study of environmental occurrence and some endocrine-disrupting activities of some bisphenols came widely into focus of research only recently. The aims of the present study were to: 1) determine the predominant bisphenols in Norwegian sewage sludge and sediment and in Czech surface waters, and 2) characterize the binding of bisphenols to a transport protein transthyretin (TTR) and their (anti-)thyroid, (anti-)progestagenic, and (anti-)androgenic activities. High-performance liquid chromatography with atmospheric pressure chemical ionization or photoionization coupled with high resolution mass spectrometry (HPLC-APCI/APPI-HRMS) and Chemically Activated LUciferase gene eXpression (CALUX) in vitro reporter gene bioassays were used to detect the target compounds and to determine endocrine-disrupting activities, respectively. Bisphenol A (BPA), 4,4′-bisphenol F (BPF), bisphenol S (BPS), and bisphenol E (BPE) were the most frequently found compounds in municipal sewage sludge. Furthermore, bisphenol TMC (BPTMC) and bisphenol AF (BPAF) frequently occurred in sediment and surface waters, respectively. BPA was the major contributor to Ʃ of bisphenols in Norwegian sewage sludge with exception of one sample where BPF predominated. We also monitored a few bisphenols in sediment but only BPTMC was found. BPA, BPAF and BPF were the dominant bisphenols in Czech surface waters. Some bisphenols have shown TTR binding potency (BPAF = BPF > BPA = BPE) and some have displayed the following endocrine-disrupting activities: anti-thyroid (BPAF), anti-progestagenic (BPTMC > BPA = BPAF), and anti-androgenic (BPAF > BPE > BPA > BPTMC > BPF > BPS). It is noteworthy that BPAF exhibited stronger or similarly potent endocrine-disrupting activities compared to BPA. Our results provide new insights into these less-studied endocrine-disrupting activities of environmentally relevant bisphenols and may be useful in prioritizing those compounds that deserve further attention in environmental monitoring and eco-toxicological research. |
| Databáze: | OpenAIRE |
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