CpG Methylation across the adipogenic PPARγ gene and its relationship with birthweight and child BMI at 9 years
| Autor: | Vitaly Volberg, Kim G. Harley, Paul Yousefi, Karen Huen, Nina Holland, Brenda Eskenazi |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
medicine.medical_specialty PPARγ Birth weight Peroxisome proliferator-activated receptor Biology Bioinformatics Body Mass Index 03 medical and health sciences Internal medicine medicine Genetics Birth Weight Humans Genetics(clinical) Epigenetics Obesity Longitudinal Studies Child Children Genetics (clinical) Newborns chemistry.chemical_classification DNA methylation Infant Newborn Methylation medicine.disease Whole blood PPAR gamma 030104 developmental biology Endocrinology CpG site chemistry Birth cohort study CpG Islands Body mass index Research Article |
| Zdroj: | BMC Medical Genetics |
| ISSN: | 1471-2350 |
| DOI: | 10.1186/s12881-016-0365-4 |
| Popis: | Background To examine methylation of the peroxisome proliferator-activated receptor γ (PPARγ) gene and its relationship with child weight status, at birth and 9 years. Methods We measured PPARγ methylation across 23 CpG sites using the Infinium Illumina 450 k array for children from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort at birth (N = 373) and 9 years (N = 245). Results Methylation level correlation patterns across the 23 PPARγ CpG sites were conserved between birth and 9-year ages. We found high inter-CpG correlations between sites 1–3 (methylation block 1) and also between sites 18–23 (methylation block 2) for both time points, although these patterns were less pronounced at 9 years. Additionally, sites 1–3 (north shore) had the highest intra-CpG correlations over time (r = 0.24, 0.42, and 0.3; P = 0.002, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|