Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgery
| Autor: | Manabu Oguchi, Hisao Tonami, Kazuya Okamoto, Kotaro Higashi, Kiyotaka Ohta, Itaru Yamamoto, Suzuka Taki, Hiroyasu Tamamura, Shiro Tsuji, Hideaki Iizuka |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Normal tissue Radiosurgery Scintigraphy Sensitivity and Specificity Lesion Technetium Tc 99m Exametazime medicine Humans Radiology Nuclear Medicine and imaging Irradiation Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test Brain Neoplasms business.industry Brain Reproducibility of Results Dose-Response Relationship Radiation General Medicine Middle Aged Radiation effect Graphic analysis Cerebral blood flow Cerebrovascular Circulation Female Radiology Radiopharmaceuticals medicine.symptom business Nuclear medicine |
| Zdroj: | Annals of Nuclear Medicine. 16:273-277 |
| ISSN: | 1864-6433 0914-7187 |
| DOI: | 10.1007/bf03000106 |
| Popis: | Objective: To elucidate the radiation effect on the normal brain after stereotactic radiosurgery (SRS), we evaluated the change in regional cerebral blood flow (CBF) in targeted and extra-targeted areas according to the radiation dose given.Methods: Thirteen patients who underwent SRS for brain tumors or arteriovenous malformations were included in this study. Maximum radiation doses to the lesion ranged from 24 to 37 Gy. Mean and regional CBF were measured by99mTc-HMPAO scintigraphy with graphic analysis, performed at before, 2 weeks and 3 months (5 patients) after SRS. Under the co-registration with the CT with superimposed isodose distribution, ROIs were set on target (37-20 Gy), peri-target (20-5 Gy) and out-of-field (5-2 Gy and less than 2 Gy) areas on the quantitative SPECT images.Results: Significant reductions in mean CBF (by 7%) and regional CBF in the peri-target areas (by 5–7%) and out-of-field areas (by 6–22%) were recognized at 2 weeks and 3 months after SRS. Regional CBF in the target and peri-target areas did not significantly change, presumably because there was little or no normal tissue in these areas.Conclusion: These results suggest that subclinical regional CBF reduction occurs after SRS in the normal brain in out-of-field of radiation. |
| Databáze: | OpenAIRE |
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