Pharmacogenomics and histone deacetylase inhibitors
| Autor: | Andrew K. L. Goey, Tristan M. Sissung, William D. Figg, Cody J. Peer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Indoles
medicine.drug_class Review Pharmacology Hydroxamic Acids 030226 pharmacology & pharmacy Romidepsin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Depsipeptides Panobinostat Genetics medicine Humans Vorinostat Sulfonamides Valproic Acid business.industry Histone deacetylase inhibitor Histone Deacetylase Inhibitors chemistry Pharmacogenetics 030220 oncology & carcinogenesis Pharmacogenomics Molecular Medicine lipids (amino acids peptides and proteins) Histone deacetylase business Belinostat medicine.drug |
| Zdroj: | Pharmacogenomics. 17:1807-1815 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs-2016-0113 |
| Popis: | The histone deacetylase inhibitor valproic acid (VPA) has been used for many decades in neurology and psychiatry. The more recent introduction of the histone deacetylase inhibitors (HDIs) belinostat, romidepsin and vorinostat for treatment of hematological malignancies indicates the increasing popularity of these agents. Belinostat, romidepsin and vorinostat are metabolized or transported by polymorphic enzymes or drug transporters. Thus, genotype-directed dosing could improve pharmacotherapy by reducing the risk of toxicities or preventing suboptimal treatment. This review provides an overview of clinical studies on the effects of polymorphisms on the pharmacokinetics, efficacy or toxicities of HDIs including belinostat, romidepsin, vorinostat, panobinostat, VPA and a number of novel compounds currently being tested in Phase I and II trials. Although pharmacogenomic studies for HDIs are scarce, available data indicate that therapy with belinostat (UGT1A1), romidepsin (ABCB1), vorinostat (UGT2B17) or VPA (UGT1A6) could be optimized by upfront genotyping. |
| Databáze: | OpenAIRE |
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