| Autor: |
Gongbo Li, Kayla M. Reid, Kristen Spitler, Nolan Beatty, Justin Boucher, Marco L. Davila |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Molecular therapy oncolytics. 24 |
| ISSN: |
2372-7705 |
| Popis: |
Allogeneic "off-the-shelf" (OTS) chimeric antigen receptor T cells (CAR-T cells) hold promise for more accessible CAR-T therapy. Here, we report a novel and simple way to make allogeneic OTS T cells targeting cancer. By engineering T cells with a bispecific T cell engager (BiTE), both TCRαβ and CD3ε expression on the T cell surface are dramatically reduced. BiTE-engineered T (BiTE-T) cells show reduced reaction to TCR stimulation |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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