Partition coefficients (free ligands and their iron(III) complexes) and lipophilic behavior of new abiotic chelators. Correlation to biological activity
| Autor: | Jean-Louis Pierre, Guy Serratrice, Fabrice Thomas, Daniel Imbert, Paul Baret |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Octanol
Octanols Clinical Biochemistry Inorganic chemistry Pharmaceutical Science Iron Chelating Agents Ligands Ferric Compounds Biochemistry chemistry.chemical_compound Phase (matter) Drug Discovery Chelation Phenols Molecular Biology fungi Organic Chemistry Aqueous two-phase system Water Biological activity Membrane transport Lipids Partition coefficient chemistry Molecular Medicine lipids (amino acids peptides and proteins) |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:3035-3040 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00527-2 |
| Popis: | Partition coefficients between n-octanol and water have been measured for ten tripodal ligands with catecholate or hydroxyquinolinate or pyridinophenolate chelating subunits and for their iron(III) complexes. The abilities of the ligands to cross an octanol phase and to extract ferric ion from its EDTA complex in an aqueous phase are studied. Correlation with biological properties are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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