Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease

Autor: Munjareen Shahnaz, Madhu S. Malo, Tapas Sarker, Pradip K. Karmakar, Jagannath Malo, Chandan K. Saha, Gopal Chandra, Md. Jahangir Alam, Ratna Paul, Kanakaraju Kaliannan, Mihir Bala, Tarek Aziz
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Article Subject
Intestinal alkaline phosphatase
Clinical Biochemistry
Myocardial Ischemia
Down-Regulation
Disease
030204 cardiovascular system & hematology
GPI-Linked Proteins
Gastroenterology
Feces
03 medical and health sciences
0302 clinical medicine
Internal medicine
Genetics
Humans
Medicine
Multiple logistic regression analysis
cardiovascular diseases
Molecular Biology
Aged
lcsh:R5-920
business.industry
Biochemistry (medical)
Case-control study
Type 2 Diabetes Mellitus
General Medicine
Odds ratio
Middle Aged
Alkaline Phosphatase
medicine.disease
body regions
Case-Control Studies
Female
030211 gastroenterology & hepatology
biological phenomena
cell phenomena
and immunity
Metabolic syndrome
lcsh:Medicine (General)
business
Ischemic heart
Biomarkers
Research Article
Zdroj: Disease Markers
Disease Markers, Vol 2019 (2019)
ISSN: 1875-8630
0278-0240
DOI: 10.1155/2019/8473565
Popis: Background. We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficiency might also be associated with IHD in humans. We aimed to determine the correlation between the IAP level and IHD in humans. Methods and Results. The IHD patients were recruited from the National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh, and the control healthy participants were recruited from a suburban community of Dhaka. We determined the IAP level in the stools of 292 IHD patients (187 males, 105 females) and 331 healthy control people (84 males, 247 females). We found that compared to controls, IHD patients have approx. 30% less IAP (mean±SEM: 63.7±3.5 vs. 44.9±2.1 U/g stool, respectively; p<0.000001), which indicates that IAP deficiency is associated with IHD, and a high level of IAP is probably protective against IHD in humans. The adjusted generalized linear model (GLM) of regression analysis predicted a strong association of IAP with IHD (p=0.0035). Multiple logistic regression analysis showed an independent inverse relationship between the IAP level and the IHD status (odds ratio, OR=0.993 with 95% CI 0.987-0.998; p<0.01). Conclusions. IAP deficiency is associated with IHD, and a high level of IAP might be protective against IHD.
Databáze: OpenAIRE
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