Differences in Infantile Growth Patterns in Turner Syndrome Girls with and without Spontaneous Puberty
| Autor: | Carl-Joachim Partsch, I. Khaesh-Goldberg, Wolfgang G. Sippell, E. Doveh, A. Cohen, T. Bistritzer, Leo Dunkel, Zeev Hochberg, Zvi Zadik |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism Birth weight Growth data Clinical Biochemistry Turner Syndrome First year of life Growth Biochemistry Growth velocity Endocrinology Internal medicine Turner syndrome Birth Weight Humans Medicine Child growth Child Retrospective Studies Models Statistical business.industry Puberty Biochemistry (medical) Infant Estrogens General Medicine medicine.disease Nonlinear Dynamics Multicenter study Estrogen Child Preschool Female business Algorithms |
| Zdroj: | Hormone and Metabolic Research. 37:236-241 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2005-861383 |
| Popis: | Objective: The role of prepubertal estrogen in child growth was modeled using Turner's syndrome, comparing growth patterns of girls who later did or did not enter puberty spontaneously. The hypothesis was that TS patientswith normal prepubertal estrogen levels would have a different growth pattern from those with subnormal estrogen levels. Study Design: Growth data from 78 full-term patients with Turner's syndrome were collected retrospectively. 24/78 later developed spontaneous puberty, (+Pub), and their growth data were compared to TS patients without spontaneous puberty (-Pub). A nonlinear mixed model was fitted using the bi-exponential model. Results: The growth velocity difference between the - Pub and + Pub groups suggests an early infantile growth advantage in the -Pub group, which disappears before the end of the first year of life; growth velocity remains similar (′ 1 cm/y) for the next 6 years and declines at age 7 - 8 years in the + Pub group faster than it does in the - Pub group. Bi-exponential analysis showed that both the 1 s t (restrictive) and 2 n d exponent (forward) were different (p=0.0003). Conclusions: Comparison of girls with or without spontaneous puberty suggests a role for estrogen in child growth. Estrogens restrict infantile growth, as well as growth during the mid-childhood spurt. |
| Databáze: | OpenAIRE |
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