Enhancer RNAs are an important regulatory layer of the epigenome
| Autor: | Vittorio Sartorelli, Shannon M. Lauberth |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
RNA
Untranslated Transcription Genetic Enhancer Elements 1.1 Normal biological development and functioning Biophysics Computational biology Biology Medical and Health Sciences Article Epigenome 03 medical and health sciences 0302 clinical medicine Genetic Underpinning research Structural Biology Transcription (biology) Neoplasms Genetics Animals Humans Enhancer Molecular Biology 030304 developmental biology Regulation of gene expression 0303 health sciences Rna processing Extramural Human Genome Untranslated RNA Biological Sciences Chromatin Enhancer Elements Genetic Gene Expression Regulation Chemical Sciences Generic health relevance Transcription 030217 neurology & neurosurgery Biogenesis Developmental Biology |
| Zdroj: | Nature structural & molecular biology, vol 27, iss 6 Nat Struct Mol Biol |
| ISSN: | 1545-9985 1545-9993 |
| DOI: | 10.1038/s41594-020-0446-0 |
| Popis: | Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function. |
| Databáze: | OpenAIRE |
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