Bile Salts Induce Resistance to Polymyxin in Enterohemorrhagic Escherichia coliO157:H7
| Autor: | Vica Dang, Ahferom Gebremedhin, Anca Serbanescu, Julianne V. Kus, Debora Barnett Foster, Seav-ly Tran |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.drug_class
Polymyxin Porins Escherichia coli O157 medicine.disease_cause Microbiology Shiga Toxin Bile Acids and Salts Lipid A Downregulation and upregulation medicine Polymyxins Molecular Biology Escherichia coli Molecular Biology of Pathogens Regulation of gene expression biology Shiga toxin Gene Expression Regulation Bacterial biochemical phenomena metabolism and nutrition Microarray Analysis Up-Regulation Genes Bacterial biology.protein Efflux Signal transduction Bacterial Outer Membrane Proteins Signal Transduction |
| Zdroj: | Journal of Bacteriology. 193:4509-4515 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.00200-11 |
| Popis: | Many enteric bacteria use bile as an environmental cue to signal resistance and virulence gene expression. Microarray analysis of enterohemorrhagic Escherichia coli O157:H7 (EHEC) treated with bile salts revealed upregulation of genes for an efflux system ( acrAB ), a two-component signal transduction system ( basRS / pmrAB ), and lipid A modification ( arnBCADTEF and ugd ). Bile salt treatment of EHEC produced a basS - and arnT -dependent resistance to polymyxin. |
| Databáze: | OpenAIRE |
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