Enantioselective Formal Synthesis of Nectrisine Using a Palladium-Catalyzed Asymmetric Allylic Amination and Cross-Metathesis as Key Steps

Autor:	Sebastien Soriano, Mariam Azzouz, Patricia Marcé, M. Isabel Matheu, Sergio Castillón, Yolanda Díaz, Josep Llaveria
Přispěvatelé:	Síntesis Orgànica Estereoselectiva, Química Analítica i Química Orgànica, Universitat Rovira i Virgili
Rok vydání:	2016
Předmět:	Allylic rearrangement Nectrisine Magnetic Resonance Spectroscopy Stereochemistry chemistry.chemical_element 010402 general chemistry Metathesis Hydroxylation 01 natural sciences Catalysis Reaccions químiques enantioselectivity Butadienes Glycoside Hydrolase Inhibitors Amines Amination 010405 organic chemistry Chemistry Organic Chemistry Enantioselective synthesis Stereoisomerism Química 0104 chemical sciences Catàlisi asimètrica Dihydroxylation Cyclization Substitution reactions Imino Furanoses Indicators and Reagents 0022-3263 Palladium
Zdroj:	Journal of Organic Chemistry
ISSN:	1520-6904
DOI:	10.1021/acs.joc.6b00494
Popis:	Filiació URV: SI A formal enantioselective synthesis of nectrisine, a potent ¿-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation, and cyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e96029a383dac08aa6429c8fae5ff99 https://pubmed.ncbi.nlm.nih.gov/27182738 Zobrazit plný text záznamu