FTO-mediated autophagy promotes progression of clear cell renal cell carcinoma via regulating SIK2 mRNA stability
| Autor: | Yawei Xu, Jingcheng Zhou, Lei Li, Wuping Yang, Zedan Zhang, Kenan Zhang, Kaifang Ma, Haibiao Xie, Zheng Zhang, Lin Cai, Yanqing Gong, Kan Gong |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Sirolimus
Carcinogenesis RNA Stability Alpha-Ketoglutarate-Dependent Dioxygenase FTO RNA-Binding Proteins Cell Biology Applied Microbiology and Biotechnology Kidney Neoplasms Mice Cell Line Tumor Autophagy Animals Humans RNA Messenger Molecular Biology Carcinoma Renal Cell Ecology Evolution Behavior and Systematics Biomarkers Developmental Biology |
| Zdroj: | International journal of biological sciences. 18(15) |
| ISSN: | 1449-2288 |
| Popis: | The progression of clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and elucidation of the molecular drivers of malignancy progression is critical for the development of effective therapeutic targets. Recent studies have demonstrated that N |
| Databáze: | OpenAIRE |
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