Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer
| Autor: | Auba Gaya-Bover, Reyniel Hernández-López, Marina Alorda-Clara, Javier M. Ibarra de la Rosa, Esther Falcó, Teresa Fernández, Maria Margarita Company, Margalida Torrens-Mas, Pilar Roca, Jordi Oliver, Jorge Sastre-Serra, Daniel Gabriel Pons |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant Colorectal cancer medicine.medical_treatment Glutathione reductase medicine.disease_cause Biochemistry Antioxidants Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Western blot medicine Biomarkers Tumor Humans Aged Neoplasm Staging chemistry.chemical_classification Aged 80 and over biology medicine.diagnostic_test Chemistry Glutathione peroxidase Cancer Cell Biology Middle Aged medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Cancer research Colorectal Neoplasms Oxidative stress |
| Zdroj: | The international journal of biochemistrycell biology. 120 |
| ISSN: | 1878-5875 |
| Popis: | Antioxidant defences and oxidative stress are related to development, progression and malignancy of colorectal cancer. However, their role in early stages of cancer remains unknown. More and more recent studies have revealed that non-tumour adjacent tissue is not a normal tissue. Thus, our aim was to analyse protein levels of MnSOD (Manganese Superoxide Dismutase), acMnSOD (Acetylated Manganese superoxide Dismutase), SIRT3 (Sirtuin 3), CuZnSOD (Cupper Zinc Superoxide Dismutase), CAT (Catalase), GPx (Glutathione Peroxidase), and GRd (Glutathione Reductase) both in tumour and non-tumour adjacent tissue from colorectal cancer patients by western blot. Non-tumour adjacent tissue seemed to have higher levels of antioxidant enzymes that detoxify hydrogen peroxide compared to tumour tissue. In contrast, tumour tissue had higher levels of MnSOD and acMnSOD. Furthermore, most of the proteins analysed showed significant differences between stage I and II in both non-tumour adjacent and tumour tissue. This could indicate that antioxidant enzymes, especially MnSOD, play a crucial role in early stages of colorectal cancer in both tissues, so they could be analysed as novel biomarkers to improve colorectal cancer diagnosis. |
| Databáze: | OpenAIRE |
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