MEMS-based silicon ultrasonic twin-nozzle nebulizer for inhalation drug delivery

Autor:	Chen S. Tsai, Gerald C. Smaldone, Matthew Brenner, Gerry R. Boss, Sari B. Mahon, Rong W. Mao, Shirley C. Tsai, Shih K. Lin
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Microelectromechanical systems Nebulizer Materials science Silicon chemistry Horn (acoustic) Nozzle chemistry.chemical_element Ultrasonic sensor Aerosolization Biomedical engineering Aerosol
Zdroj:	Mao, RW; Lin, SK; Tsai, SC; Brenner, M; Mahon, S; Boss, G; et al.(2014). MEMS-based silicon ultrasonic twin-nozzle nebulizer for inhalation drug delivery. IEEE International Ultrasonics Symposium, IUS, 742-744. doi: 10.1109/ULTSYM.2014.0183. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3sc6k2jx
Popis:	© 2014 IEEE. A versatile silicon-based ultrasonic nebulizer that utilizes a twin-nozzle of multiple Fourier horns at 1-2 MHz drive frequencies has been realized to perform simultaneous aerosolization of cobinamide and magnesium thiosulfate drug solutions. The drive frequency of the individual nozzle for a desirable aerosol diameter was individually designed. Using the 2.0 MHz 4-Fourier horn twin-nozzle aerosols of the two drug solutions with mass median diameter (MMD) of 3.0±0.1μm and geometrical standard deviation (GSD) of 1.18±0.02 and total flow rate up to 400μL/min were produced.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9463165edd0aa329d441cbe9e8d2ac http://www.escholarship.org/uc/item/3sc6k2jx Zobrazit plný text záznamu