Positivity rate of interferon-γ release assays for estimating the prevalence of latent tuberculosis infection in renal transplant recipients in Japan
| Autor: | Hidetoshi Igari, Naotake Akutsu, Kiminori Suzuki, Satoru Ishikawa, Mizue Tsuyuzaki, K. Otsuki, Hiromichi Aoyama, Michihiro Maruyama, Kenichi Saigo, Masayuki Hasegawa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Graft Rejection Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Concordance 030106 microbiology Gastroenterology Immunocompromised Host Young Adult 03 medical and health sciences 0302 clinical medicine Japan Interferon γ Latent Tuberculosis Active tb Internal medicine Prevalence medicine Humans Pharmacology (medical) 030212 general & internal medicine T-SPOT.TB Aged Antigens Bacterial Latent tuberculosis business.industry Significant difference Mycobacterium tuberculosis Middle Aged bacterial infections and mycoses medicine.disease Kidney Transplantation Transplant Recipients Cross-Sectional Studies Infectious Diseases Renal transplant Female business Immunosuppressive Agents Interferon-gamma Release Tests CD8 |
| Zdroj: | Journal of Infection and Chemotherapy. 25:537-542 |
| ISSN: | 1341-321X |
| Popis: | Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and developing active tuberculosis. QuantiFERON®-TB Gold Plus (QFT-Plus) has two TB-specific antigens tubes (TB1 and TB2). TB1 elicits CD4 T-cell response, and TB2 elicits both CD4 and CD8 T-cells responses, with expected increased sensitivity. The aim of this study was to estimate the prevalence of LTBI in renal transplant recipients in Japan. We conducted a cross-sectional study by using two interferon-γ release assays (IGRAs), QFT-Plus and T-SPOT®.TB (TSPOT). One hundred thirty-five recipients were prospectively enrolled. The median age was 49 years (range: 20 to 79). The positivity rates of QFT-Plus and TSPOT were 5.9% (95%CI 3.0-11.3) and 3.7% (95%CI 1.6-8.4), respectively, with no significant difference. The concordance rate was 95.5% (κ coefficient, 0.76). Age of 60 years and higher was related to the higher positivity rate in both QFT-Plus and TSPOT. The positivity rates of TB1 and TB2 were 5.1% (95%CI 2.5-10.2) and 5.9% (95%CI 3.0-11.2), respectively, with no significant difference. The concordance rate was 99.3% (κ coefficient, 0.93). TB2 did not show a higher positivity rate compared with TB1. The estimated prevalence of LTBI by using the both IGRAs was 3.7-5.9% in renal transplant recipients. These results were equivalent to the IGRAs positivity rate in the general Japanese population, even under the condition of immunosuppressive therapy. In consideration of the higher risk of developing active TB from LTBI, we can use both IGRAs as acceptable tools for LTBI diagnosis in renal transplant recipients. |
| Databáze: | OpenAIRE |
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