Eosinophilic pneumonia induced by non-steroidal anti-inflammatory drugs: An underestimated risk
| Autor: | Malak Abou Taam, Brahim Azzouz, Aurore Morel, Thierry Trenque, Josette Biya, Francois Krabansky |
|---|---|
| Přispěvatelé: | Vieillissement, Fragilité (VIEFRA - EA 3797), Université de Reims Champagne-Ardenne (URCA) |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Diclofenac Analgesic Piroxicam 030226 pharmacology & pharmacy Pharmacovigilance 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Prevalence medicine Eosinophilic pneumonia Humans Pharmacology (medical) Medical history Pulmonary Eosinophilia ComputingMilieux_MISCELLANEOUS business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged 030224 pathology Ibuprofen medicine.disease Arthralgia 3. Good health [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Female business Adverse drug reaction medicine.drug |
| Zdroj: | Thérapie Thérapie, EDP Sciences, 2018, 73 (6), pp.473-482. ⟨10.1016/j.therap.2018.03.005⟩ |
| ISSN: | 0040-5957 1958-5578 |
| DOI: | 10.1016/j.therap.2018.03.005 |
| Popis: | Summary Introduction Eosinophilic pneumonia (EP) is a rare but serious adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs). Methods We describe the second published case of EP induced by oral diclofenac. We also reviewed the literature as well as French pharmacovigilance database. Case presentation A 63 year-old woman with polyarthralgia had taken diclofenac for three days for analgesic purposes. Progressively, the patient presented weakness, dyspnea and fever. Computed tomography (CT) scan revealed bilateral interstitial infiltration. Broncho-alveolar lavage (BAL) showed an elevated level of eosinophils. After ruling out all other possible etiologies, drug-induced EP was diagnosed and treatment by corticosteroid was initiated. The patient recovered in three months. Results In the French pharmacovigilance database, six cases of EP were recorded (3 with naproxen, 2 with ibuprofen, 1 with piroxicam). In the literature, twenty-six cases of EP with NSAIDs were published. The most commonly involved drug was naproxen (n = 8), followed by fenbufen (n = 4), ibuprofen (n = 3) and diclofenac (n = 2). A high level of eosinophils was systematically observed in the blood cell count or BAL. Corticosteroid therapy was started in eleven cases. All patients recovered. Conclusion Complete history taking and examination should be done to rule out other etiological diagnoses. BAL is sufficient to diagnose EP. Corticosteroid therapy should be indicated for more severe or refractory cases. This adverse drug reaction is underestimated, healthcare professionals should be informed. |
| Databáze: | OpenAIRE |
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