Heterobifunctional molecules tackle targeted protein dephosphorylation

Autor:	Christopher D. Sibley, John S. Schneekloth
Rok vydání:	2022
Předmět:	Pharmacology Humans Phosphorylation Phosphoproteins Toxicology Protein Processing Post-Translational
Zdroj:	Trends in Pharmacological Sciences. 43:263-265
ISSN:	0165-6147
DOI:	10.1016/j.tips.2022.01.005
Popis:	Recently, Chen and colleagues reported the development of phosphatase-targeting chimeric molecules (PhosTACs), heterobifunctional small molecules that promote targeted, proximity-induced protein dephosphorylation. This strategy represents an innovative approach to selectively manipulate phosphoprotein function and provides proof-of-concept for a new class of bifunctional small molecules in the chemical biologist's toolbox.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e919c0d64ac6a0cd85c633dff8a71a6 https://doi.org/10.1016/j.tips.2022.01.005 Zobrazit plný text záznamu Full Text from ScienceDirect