Spatial Comparison of CT-Based Surrogates of Lung Ventilation With Hyperpolarized Helium-3 and Xenon-129 Gas MRI in Patients Undergoing Radiation Therapy
| Autor: | Guilhem Collier, Bilal A Tahir, Helen Marshall, Alberto Biancardi, Rob H. Ireland, Graham Norquay, Neil J. Stewart, Paul Hughes, Ho-Fung Chan, James A. Swinscoe, Stephen Robinson, Matthew Q. Hatton, Jame M. Wild, Kerry Hart |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Lung Neoplasms Image registration Hyperpolarized Helium 3 computer.software_genre Helium Spearman's rank correlation coefficient 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Isotopes Voxel Hounsfield scale medicine Humans Radiology Nuclear Medicine and imaging Aged Radiation Lung business.industry Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Breathing Xenon Isotopes Female Tomography Pulmonary Ventilation Tomography X-Ray Computed Nuclear medicine business computer |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 102:1276-1286 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2018.04.077 |
| Popis: | Purpose To develop and apply an image acquisition and analysis strategy for spatial comparison of CT-ventilation images with hyperpolarized gas MRI. Methods 11 lung cancer patients underwent 129Xe and 3He ventilation MRI and co-registered 1H anatomical MRI. Expiratory and inspiratory breath-hold CTs were used for deformable image registration and calculation of three CT-ventilation metrics: Hounsfield unit (CTHU), Jacobian (CTJac) and specific gas volume change (CTSGV). Inspiration CT and hyperpolarized gas ventilation MRI were registered via same-breath anatomical 1H-MRI. Voxel-wise Spearman correlation coefficients were calculated between each CT-ventilation image and its corresponding 3He/129Xe-MRI, and for the mean values in regions of interest (ROIs) ranging from fine to coarse in-plane dimensions of 5x5, 10x10, 15x15 and 20x20, located within the lungs as defined by the same-breath 1H-MRI lung mask. Correlation of 3He and 129Xe-MRI was also assessed. Results Spatial correlation of CT-ventilation against 3He/129Xe-MRI increased with ROI size. For example, for CTHU, mean±SD Spearman coefficients were 0.37±0.19/0.33±0.17 at the voxel-level and 0.52±0.20/0.51±0.18 for 20x20 ROIs, respectively. Correlations were stronger for CTHU than for CTJac or CTSGV. Correlation of 3He with 129Xe-MRI was consistently higher than either gas against CT-ventilation maps over all ROIs (p |
| Databáze: | OpenAIRE |
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