Point of care testing of Influenza A/B and RSV in an adult respiratory assessment unit is associated with improvement in isolation practices and reduction in hospital length of stay
| Autor: | Louise Lansbury, Louise Berry, Wei Shen Lim, Lydia Gale, Ann Marie Carroll |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Isolation (health care) Influenzavirus B Point-of-care testing Point-of-Care Systems respiratory syncytial virus 030106 microbiology Comorbidity respiratory tract infections Microbiology Disease Diagnosis and Diagnostics 03 medical and health sciences Internal medicine Influenza Human medicine Infection control Humans Respiratory system GeneXpert MTB/RIF Respiratory tract infections business.industry General Medicine Length of Stay Respiratory Syncytial Viruses 030104 developmental biology medicine.anatomical_structure Molecular Diagnostic Techniques Influenza A virus Point-of-Care Testing Respiratory virus Female point-of-care test business influenza isolation Respiratory tract Research Article |
| Zdroj: | Journal of Medical Microbiology |
| ISSN: | 1473-5644 |
| Popis: | Introduction. Every winter seasonal influenza and other viral respiratory infections increase pressure on the health services and are associated with nosocomial infection and morbidity. Aim. To compare provision of point-of-care (POC) testing with laboratory-based testing for influenza and RSV detection on an adult respiratory assessment unit to assess the impact on isolation practices and length of stay (LOS). Methodology. Prospective interrupted ‘on-off’ study in adults admitted to the respiratory unit between December 2018 and April 2019 with a suspected respiratory tract infection. Nasopharyngeal samples were tested using either the GeneXpert rapid POC test for influenza and RSV (on-period), or were sent to the laboratory for multiplex PCR testing against a panel of 12 respiratory viruses (off-period). Outcome measures were time to patient isolation for infection control, LOS and turnaround time from admission to test results. Results. Of 1145 patients evaluated, 755 were tested with POC and 390 with laboratory multiplex; a respiratory virus was identified in 164 (21.7 %) and 138 (35.4 %) patients respectively. A positive POC test was associated with a shorter time to isolation (mean difference 16.9 h, P [less than] 0.001), shorter LOS (mean difference 15.5 h, P=0.05,) and shorter turnaround time (mean difference 28.3 h, P[less than] 0.001), compared to laboratory testing. Conclusion. Use of GeneXpert POC testing for Flu/RSV is associated with rapid reporting of results with significant improvements in isolation practices and reductions in LOS. |
| Databáze: | OpenAIRE |
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