Granulocytic sarcoma: 32 cases and review of the literature
Autor: | Melek Ergin, Suzan Zorludemir, Semra Paydas |
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Přispěvatelé: | Çukurova Üniversitesi |
Rok vydání: | 2006 |
Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Myeloid Adolescent Biopsy Granulocytic sarcoma Medical Oncology Diagnosis Differential hemic and lymphatic diseases MDS medicine Myeloid sarcoma Humans Sarcoma Myeloid Lymph node Aged Acute myeloid leukemia medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin Chronic myeloid leukemia Soft tissue Hematology Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Lymphoma Leukemia Treatment Outcome medicine.anatomical_structure Oncology Female Sarcoma business Stem Cell Transplantation |
Zdroj: | Leukemia & Lymphoma. 47:2527-2541 |
ISSN: | 1029-2403 1042-8194 |
Popis: | PubMedID: 17169797 Thirty-two cases of granulocytic sarcoma (GS) are reported in this paper. Age range was from 16-70 years. GS was accompanied by AML in 13 cases, ALL (My+) in one case, CML in 11 cases and MDS in two cases. GS was diagnosed simultaneously with leukemia in five cases and preceded the leukemia in eight. Lymph node and soft tissue were the most commonly detected localizations. Seven cases had first been diagnosed as NHL. Histopathologically blastic, immature and mature variants were found in 11, nine and 11 cases respectively and overall survival was shortest in the blastic type. Myeloperoxidase and lysozyme were found to be positive in 30 and 24 cases respectively. Therapy was radiation in five cases and surgery in three. Systemic chemotherapy was given to the cases. The clinical outcome of the patients after the diagnosis of GS was poor. GS is a unique entity; prognosis is poor but it is important to detect the signaling pathways associated with migration of myeloid cells to the extra-medullary tissues. The critical factors for detecting this interesting tumor are to be aware of this disease, cooperation between clinician and pathologist and the application of special stains to detect the myeloid origin. |
Databáze: | OpenAIRE |
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