Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology
| Autor: | Seung-Sook Lee, Myung-Soon Shin, Sunhoo Park, Hwa Jeong Ha, Eun Ju Kim, Jung-Soon Kim, Insup Noh, Jae Soo Koh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Medicine (General)
Pathology medicine.medical_specialty diagnostic pitfalls Biopsy Fine-Needle fine needle aspiration cytology Metastatic papillary thyroid carcinoma thyroid lesion Article Diagnosis Differential R5-920 Fine needle aspiration cytology medicine Humans Thyroid Neoplasms Retrospective Studies Parathyroid adenoma Benign disease business.industry Thyroid parathyroid lesion General Medicine Hyperplasia medicine.disease medicine.anatomical_structure Parathyroid carcinoma Differential diagnosis business |
| Zdroj: | Medicina; Volume 56; Issue 11; Pages: 558 Medicina Medicina, Vol 56, Iss 558, p 558 (2020) Volume 56 Issue 11 |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina56110558 |
| Popis: | Background: It is difficult to distinguish parathyroid lesions (PLs) from thyroid lesions using fine needle aspiration cytology (FNAC) because of their proximity and their similar cytomorphological features. Methods: FNAC smears of 46 patients with pathologically proven PLs that were histologically diagnosed as parathyroid adenoma (PA, n = 35), parathyroid hyperplasia (PH, n = 3), atypical parathyroid adenoma (APA, n = 1), and parathyroid carcinoma (PC, n = 7) were retrospectively reviewed and analyzed. Results: Our initial cytological diagnoses indicated correct diagnoses in 31 of 46 PL patients (67%). The 15 erroneous diagnoses were 5 patients with non-specific benign disease (11%), 4 with nodular hyperplasia of the thyroid (9%), 5 with atypical cells (11%), and 1 with a metastatic papillary thyroid carcinoma (2%). Follicular pattern, papillary structures, colloid-like material, and macrophages, which often suggest thyroid lesions, were also present in some PLs. We found that branching capillaries along the papillary structures, stippled nuclear chromatin, and frequent occurrence of naked nuclei were useful for determining a parathyroid origin. Conclusions: It is important to be aware that PLs are frequently mistaken for thyroid lesions based on FNAC. The specific and unique characteristics of PLs identified here may be helpful in diagnosis. |
| Databáze: | OpenAIRE |
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