Effects of delaying puberty on bone mineralization in female rats
| Autor: | Yardena Rakover, Ehud Weiner, Chang Tao, Izhar Ben-Shlomo, Christopher T. Cowell, Julie Briody, Antwan G.H. Ederveen, Peggy Lu |
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| Rok vydání: | 2000 |
| Předmět: |
musculoskeletal diseases
Aging medicine.medical_specialty Time Factors Bone density Gonadotropin-releasing hormone Hormone antagonist Gonadotropin-Releasing Hormone Rats Sprague-Dawley Absorptiometry Photon Hormone Antagonists Bone Density Internal medicine medicine Animals Sexual maturity Femur Puberty Delayed Bone mineral business.industry Rehabilitation Obstetrics and Gynecology musculoskeletal system Hormones Rats medicine.anatomical_structure Endocrinology Reproductive Medicine Female Cortical bone Tomography X-Ray Computed business Hormone |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1460-2350 0268-1161 |
| Popis: | The effect of delaying puberty on bone mineralization was studied using female rats as a model. Repeated injections of gonadotrophin-releasing hormone antagonist (GnRHa) were used to suppress the onset of puberty from the age of 6-10 weeks. A group of control female rats was given aqueous solution injections at the same age and for the same duration. The effect of delaying puberty on bone mineralization was examined using dual energy X-ray absorptiometry (DXA) and peripheral quantitative computerized tomography (QCT), both methods being adapted for small animals. Bone mineral parameters were measured at baseline and at the ages of 10, 17 and 24 weeks in total body, femur and spine. Compared to controls, bone mineral content (BMC) and bone mineral density (BMD), as measured by DXA, were significantly decreased in GnRHa-treated rats in total body and femur at 10 and 24 weeks of age (P < 0.05). The results were even more significant after adjusting for weight. After this adjustment, spine BMC and BMD at 10, 17 and 24 weeks were significantly lower in the treatment group (P < 0.05). Trabecular BMD at the distal femur in the GnRHa treated group as measured by peripheral QCT was significantly lower (P < 0.05). However, cortical bone in the mid-femur had higher BMD, concurrent with lower cortical thickness in the treatment group. In conclusion, a delay in the onset of sexual maturation may cause prolonged, possibly irreversible defect in bone mineralization. |
| Databáze: | OpenAIRE |
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