Physical Characterization of Halofantrine-Encapsulated Fat Nanoemulsions
| Autor: | Ian H. Harding, Ian C. Bowater, Alasdair W. McDowall, Iman Haidar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Drug Compounding Dispersity Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Soybean oil Antimalarials 03 medical and health sciences Colloid chemistry.chemical_compound 0302 clinical medicine food Drug Stability Microscopy Electron Transmission Halofantrine Zeta potential Isoelectric Point Particle Size Drug Carriers Chemistry Hydrogen-Ion Concentration Phenanthrenes 021001 nanoscience & nanotechnology Soybean Oil Isoelectric point Chemical engineering Emulsion Nanoparticles Emulsions Particle size 0210 nano-technology |
| Zdroj: | Journal of Pharmaceutical Sciences. 108:2153-2161 |
| ISSN: | 0022-3549 |
| DOI: | 10.1016/j.xphs.2019.01.021 |
| Popis: | We report the colloidal characterization of halofantrine (Hf)-laden soybean oil fat emulsions. Hf increased the zeta potential, at all pH values, of the fat emulsions. Concomitant with this, the isoelectric point (i.e.p.) of the emulsion increased to higher pH values. The emulsion was destabilized by a small amount of Hf; interestingly, however, this was ameliorated by increasing the amount of Hf. The particle size and polydispersity of the fat emulsion reflected this with a small Hf concentration resulting in a significant increase in both particle size and polydispersity, but less so as the Hf concentration was increased. Emulsions lost stability as the pH approached the i.e.p. and this effect was greatest for the small Hf concentration emulsions. Cryogenic transmission electron microscopy showed the presence of beading or string-like behavior leading to gross distortions of the spherical shape for highly unstable emulsions. We conclude that to maintain good stability for Hf-laden soybean oil emulsions, the pH of the emulsion should be kept away from its i.e.p, and also that the drug concentration should be maintained at a relatively high value. |
| Databáze: | OpenAIRE |
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