Tumour necrosis factor‐α and interleukin‐1 and ‐6 in fibrocystic breast disease
| Autor: | Angel Ramírez, Salomón Menjón, Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Fibrocystic Breast Disease medicine.medical_treatment Breast Neoplasms Risk Assessment Breast cancer Risk Factors Internal medicine Linear regression medicine Humans Testosterone Cyst Interleukin 6 Estradiol biology Dehydroepiandrosterone Sulfate Tumor Necrosis Factor-alpha business.industry 17-alpha-Hydroxyprogesterone Interleukin-8 Sodium Interleukin Exudates and Transudates Middle Aged medicine.disease Cytokine Endocrinology Oncology Potassium biology.protein Regression Analysis Female Tumor necrosis factor alpha business Interleukin-1 |
| Zdroj: | Breast Cancer Research and Treatment. 54:159-164 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1023/a:1006174931004 |
| Popis: | The risk of developing breast cancer is higher in women presenting gross cystic disease (cysts3 mm in diameter) of the breast with intracystic K+/Na+3 as compared with K+/Na+3. The present study reports the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6) in the breast cyst fluid of women with gross cystic disease and analyses the relationship between the intracystic concentration of these cytokines, sex steroid hormones, and the K+/Na+ ratio. The concentration of these cytokines, estradiol, testosterone, dehydroepiandrosterone sulfate (DHEA-S), and 17-OH-progesterone were determined in the breast cyst fluid of 54 women with gross cystic disease. No significant differences were found in the cystic levels of IL-1 between cysts with intracystic K+/Na+3 and3. However, in cysts with intracystic K+/Na+3 we found a lower concentration of IL-6 and TNF-alpha than in those with intracystic K+/Na+3. Stepwise multiple linear regression analysis demonstrated that the concentration of IL-6 in breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA-S, and by a positive regression coefficient for the concentration of TNF-alpha. The concentration of TNF-alpha in breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL-6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL-1 in breast cyst fluid. Our results indicate that IL-6 and TNF-alpha could have a local 'protector' role in gross cystic disease, and that they could be used as a marker to identify cyst type. |
| Databáze: | OpenAIRE |
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