Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review
Autor: | Silvia Fialová, Lívia Slobodníková, Katarína Rendeková, Milan Nagy, Pavel Mučaji |
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Rok vydání: | 2021 |
Předmět: |
QH301-705.5
wound healing Legislation Context (language use) Review Skin infection Catalysis Inorganic Chemistry Antibiotic resistance EMA skin inflammation Humans Medicine Biology (General) Physical and Theoretical Chemistry Medicinal plants QD1-999 Molecular Biology Spectroscopy Pharmaceutical industry Folk medicine Plants Medicinal antimicrobial activity Traditional medicine Plant Extracts business.industry Organic Chemistry Skin Diseases Bacterial General Medicine folk medicine medicine.disease plant secondary metabolites Anti-Bacterial Agents skin infections Computer Science Applications Chemistry HMPC Wound Infection herbal drugs Medicine Traditional business Antibacterial activity Phytotherapy |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 10746, p 10746 (2021) |
ISSN: | 1422-0067 |
Popis: | Bacterial infections of skin and wounds may seriously decrease the quality of life and even cause death in some patients. One of the largest concerns in their treatment is the growing antimicrobial resistance of bacterial infectious agents and the spread of resistant strains not only in the hospitals but also in the community. This trend encourages researchers to seek for new effective and safe therapeutical agents. The pharmaceutical industry, focusing mainly on libraries of synthetic compounds as a drug discovery source, is often failing in the battle with bacteria. In contrast, many of the natural compounds, and/or the whole and complex plants extracts, are effective in this field, inactivating the resistant bacterial strains or decreasing their virulence. Natural products act comprehensively; many of them have not only antibacterial, but also anti-inflammatory effects and may support tissue regeneration and wound healing. The European legislative is in the field of natural products medicinal use formed by European Medicines Agency (EMA), based on the scientific work of its Committee on Herbal Medicinal Products (HMPC). HMPC establishes EU monographs covering the therapeutic uses and safe conditions for herbal substances and preparations, mostly based on folk medicine, but including data from scientific research. In this review, the medicinal plants and their active constituents recommended by EMA for skin disorders are discussed in terms of their antibacterial effect. The source of information about these plant products in the review is represented by research articles listed in scientific databases (Science Direct, PubMed, Scopus, Web of Science, etc.) published in recent years. |
Databáze: | OpenAIRE |
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