Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome
| Autor: | Fiona Howells, Linda Nicol, Katarzyna Siemienowicz, W.C. Duncan, Chloe H Anderson, Michael T. Rae, Stephen Franks |
|---|---|
| Přispěvatelé: | MRC |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Sheep Physiology Adipose tissue 02 engineering and technology Pathophysiology Article 03 medical and health sciences Weight loss Internal medicine medicine lcsh:Science Multidisciplinary biology business.industry Insulin Biological Sciences 021001 nanoscience & nanotechnology Polycystic ovary Insulin receptor 030104 developmental biology Endocrinology Postprandial biology.protein lcsh:Q medicine.symptom 0210 nano-technology business Thermogenesis Weight gain |
| Zdroj: | iScience, Vol 23, Iss 6, Pp 101164-(2020) iScience Siemienowicz, K, T Rae, M T, Howells, F, Anderson, C, Nicol, L, Franks, S & Duncan, W C 2020, ' Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS) ', iScience, vol. 23, no. 6 . https://doi.org/10.1016/j.isci.2020.101164 |
| ISSN: | 2589-0042 |
| DOI: | 10.1016/j.isci.2020.101164 |
| Popis: | Summary Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically realistic preclinical model to investigate the molecular basis for the reduced postprandial thermogenesis (PPT) and develop a therapeutic strategy to normalize this deficit. Sheep exposed to increased androgens before birth develop the clinical features of PCOS. In adulthood they develop obesity and demonstrate an obesity-independent reduction in PPT. This is associated with reduced adipose tissue uncoupling protein expression and adipose tissue noradrenaline concentrations. These sheep are insulin resistant with reduced insulin signaling in the brain. Increasing brain insulin concentrations using intranasal insulin administration increased PPT in PCOS sheep without any effects on blood glucose concentrations. Intranasal insulin administration with food is a potential novel strategy to improve adaptive energy expenditure and normalize the responses to weight loss strategies in women with PCOS. Graphical Abstract Highlights • Obesity can be prenatally programmed by androgens in an ovine model of PCOS • This model has the same deficit in postprandial energy expenditure as women with PCOS • Reduced adipose tissue thermogenesis links to lower central insulin signaling • Therapeutic intranasal insulin raises postprandial energy expenditure in PCOS sheep Pathophysiology; Sheep Physiology; Biological Sciences |
| Databáze: | OpenAIRE |
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