Effects of Inoculation with Attenuated Autologous T Cells in Patients with Rheumatoid Arthritis
| Autor: | F.C. Breedveld, André M. M. Miltenburg, R. R. P. De Vries, B.G. Elferink, M.R. Daha, J. M. Van Laar, M. J. A. Verdonk, Irun R. Cohen, A. Leow |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Immunology T-cell vaccination Lymphocyte Activation Peripheral blood mononuclear cell Autoimmune Diseases Arthritis Rheumatoid Antigen Rheumatoid Factor Synovial Fluid medicine Humans Immunology and Allergy Synovial fluid Aged Autoantibodies Immunosuppression Therapy Autoimmune disease business.industry Synovial Membrane Immunotherapy Active T lymphocyte Middle Aged medicine.disease Immunoglobulin M Immunoglobulin G Rheumatoid arthritis Feasibility Studies Female Clone (B-cell biology) business |
| Zdroj: | Journal of Autoimmunity. 6:159-167 |
| ISSN: | 0896-8411 |
| DOI: | 10.1006/jaut.1993.1013 |
| Popis: | Injection of attenuated autoimmune T cells, T cell vaccination, has been used successfully in the prevention and treatment of experimental animal autoimmune disease. In order to determine whether such a procedure might be applied in rheumatoid arthritis (RA), a phase I study was conducted in thirteen RA patients with a mean disease duration of 12.8 years. All patients received a subcutaneous injection of attenuated autologous T lymphocytes from a CD4 positive clone ( n = 4) or line ( n = 9) isolated from synovial tissue ( n = 3) or synovial fluid ( n = 10). No toxic side effects were observed. On the average the patients showed a slight decrease in disease activity which was most marked at 8 weeks after the injection. Specific immune reactivity against the injected T cells was not detected, with the possible exception of one patient who was vaccinated with a clone selected in vitro with antigen and whose disease had begun one year earlier. In this patient a clear decrease in disease activity occurred, which was associated with a decrease in mitogen-induced proliferation of her peripheral blood mononuclear cells and in titres of serum rheumatoid factors. The results of this study show that inoculation of RA patients with autologous T cells is technically feasible and non-toxic, and may be associated with clinical and immunological effects. The data suggest that the potential of T cell vaccination should be further explored in diseases with defined antigen reactivity. |
| Databáze: | OpenAIRE |
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