Insulin effects on the left ventricle in older hypertensive subjects
| Autor: | Anna Maria De Propris, Maria Gabriella Di Bernardo, Vincenzo Marigliano, Angelo Scuteri |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Aging Time Factors Heart disease medicine.medical_treatment Ventricular Function Left Muscle hypertrophy Internal medicine Hyperinsulinism medicine Hyperinsulinemia Humans Insulin Interventricular septum Pancreatic hormone Aged Aged 80 and over Analysis of Variance business.industry Glucose Tolerance Test Middle Aged medicine.disease Blood pressure medicine.anatomical_structure Endocrinology Ventricle Echocardiography Hypertension Cardiology Female Hypertrophy Left Ventricular Geriatrics and Gerontology business |
| Zdroj: | Journal of the American Geriatrics Society. 47(6) |
| ISSN: | 0002-8614 |
| Popis: | BACKGROUND: To evaluate the effects of hyperinsulinemia on left ventricular (LV) structure and function in older hypertensive subjects METHODS: Thirty-seven hypertensive subjects (17 men/20 women) aged 50 to 80, were studied. LV mass were evaluated echocardiographically according to the Penn convention. A 75-g oral glucose tolerance test (OGTT) was performed after overnight fasting, and both blood glucose and insulin concentrations were assayed at 0, 30, 60, 90, 120, and 180 minutes. Comparison between groups was performed by analysis of variance. A P value of .05 was considered statistically significant. RESULTS: When the hypertensive patients were divided into two groups according to the median value of 2-hour post-loading plasma insulin, there was no difference in blood pressure levels between the groups. However, hyperinsulinemic hypertensive subjects had an increased LV mass (P < .05), mean wall thickness, and interventricular septum thickness (P < .05 for both parameters) and had better systolic function-ejection and shortening fractions (P < .0001 for both indices). CONCLUSIONS: Hyperinsulinemia may be associated with increased left ventricular mass and with a better systolic performance in older hypertensive subjects. J Am Geriatr Soc 47:727–729, 1999. |
| Databáze: | OpenAIRE |
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