Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia

Autor:	Marco Antonio Jiménez López, Marco Antonio Leyva‑Vázquez, Jazmin Gómez‑Santamaria, Berenice Illades‑Aguiar, Mónica Virginia Saavedra‑Herrera, Ana Ramírez, Jorge Organista‑Nava, Yazmín Gómez‑Gómez, Oscar Del Moral Hernández
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	relapse Cancer Research Acute leukemia resistance to methotrexate biology business.industry MTHFD1 Articles RFC1 folate Molecular medicine MTRR methotrexate Real-time polymerase chain reaction Oncology Methylenetetrahydrofolate reductase Gene expression Cancer research biology.protein Medicine acute leukemia business
Zdroj:	Oncology Letters
ISSN:	1792-1082 1792-1074
Popis:	The present study analyzed the mRNA expression levels of genes involved in the transport and metabolism of methotrexate (MTX) (RFC1, ABCC1, ABCB1, GGH, FPGS, ATIC, TS, MTHFR, MTRR, MS and MTHFD1) in patients with acute leukemia (AL). The expression levels of the examined genes were analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in patients with AL (ALL:50/AML:19) and 66 healthy individuals. The mRNA expression levels of RFC1, MS, MTRR, MTHFR and ABCB1 were decreased (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e80ec88beef2e47e679726219bcaee8 http://europepmc.org/articles/PMC6704278 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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