Bilateral anorchia in infancy: Occurence of micropenis and the effect of testosterone treatment
| Autor: | C. Pienkowski, Frédérique Dijoud, Marc Nicolino, Anne-Marie Bertrand, Juliane Léger, Claire Nihoul-Fékété, S. Soskin, M. Bost, C. Bouvatier, Y. Morel, Alaa El-Ghoneimi, Pierre Mouriquand, D. Zenaty, Sylvie Cabrol, G. Pinto, C. Lecointre |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Penile Diseases Time Factors Urologic Surgical Procedures Male Anorchia medicine.drug_class Urology Physical examination Genitalia Male Internal medicine medicine Humans Endocrine system Eunuchism Testosterone Child Spermatic Cord Torsion medicine.diagnostic_test business.industry Infant Newborn Infant Micropenis medicine.disease Androgen Treatment Outcome medicine.anatomical_structure Endocrinology Child Preschool Pediatrics Perinatology and Child Health Androgens Gestation France business Penis |
| Zdroj: | The Journal of Pediatrics. 149:687-691 |
| ISSN: | 0022-3476 |
| Popis: | Objective To analyze the clinical and histological findings in boys with bilateral anorchia and the response to testosterone treatment on penis length. Study design Patients were divided into two groups according to the absence (group A, n = 29) or the presence (group B, n = 26) of palpable intrascrotal or inguinal mass at first clinical examination. Results A micropenis was found in 46% of patients (n = 24) with a similar proportion in both groups. Testosterone treatment induced a mean penis length gain of 1.9 ± 1.3 SDS (standard deviation score). However, micropenis persisted in six patients. Histological examination (n = 18) confirmed the absence of any testicular structure with deferent ducts being present unilaterally or bilaterally in all but three patients. In these three patients, a hemorrhagic testis, probably as a result of a mechanical torsion, was found. Conclusions The presence of isolated micropenis in almost half of patients with bilateral anorchia strongly suggests that the testicular damage frequently occurs during the second half of gestation after male sexual differentiation. In most cases, testosterone treatment stimulates the penile growth. Although the pathogenesis of bilateral anorchia may be heterogeneous, our study suggests that gonads may have been functionally abnormal before they disappeared, and suggests that some patients have an intrinsic endocrine disorder. |
| Databáze: | OpenAIRE |
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