Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency
| Autor: | Darius Armstrong-James, Zoe Adhya, Michael R. Loebinger, Jimstan Periselneris, P. Macedo, Silke Schelenz, W Peter Kelleher |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Referral Primary Immunodeficiency Diseases medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunodeficiency Retrospective Studies COPD Bronchiectasis biology Pseudomonas aeruginosa business.industry Common variable immunodeficiency medicine.disease Primary and secondary antibodies Common Variable Immunodeficiency 030104 developmental biology 030228 respiratory system biology.protein business Complication |
| Zdroj: | Thorax. 76:1036-1039 |
| ISSN: | 1468-3296 0040-6376 |
| DOI: | 10.1136/thoraxjnl-2020-215585 |
| Popis: | Bronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective analysis of patients with CVID and specific antibody deficiency in two tertiary referral centres with lung disease was conducted. Severity of bronchiectasis at presentation was associated with mortality. Lower FEV1, colonisation with Pseudomonas aeruginosa and a diagnosis of COPD were also associated with mortality. Bronchiectasis is an important driver of mortality in patients with PAD syndromes. |
| Databáze: | OpenAIRE |
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