Complement component 3 and its activation split-products in saliva associate with periodontitis
| Autor: | Christian Damgaard, Laura Massarenti, Anne Katrine Danielsen, Jonas H. Graversen, Palle Holmstrup, Claus H. Nielsen, Yaseelan Palarasah |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Damgaard, C, Massarenti, L, Danielsen, A K, Graversen, J H, Holmstrup, P, Nielsen, C H & Palarasah, Y 2022, ' Complement component 3 and its activation split-products in saliva associate with periodontitis ', Journal of Periodontology, vol. 93, no. 9, pp. 1294-1301 . https://doi.org/10.1002/JPER.21-0530 |
| Popis: | Background: Periodontitis (PD) is classified by Grades A through C according to the risk of further progression, PD Grade C (PD-C) being the most severe progressing form. It is a matter of controversy, whether the disease activity observed in PD-C is due to impaired immune reactivity toward bacteria embedded in biofilms or a hyper-reactive immune response causing tissue damage as a bystander phenomenon. Little is known about the role of complement in this respect. Methods: Plasma and unstimulated saliva samples were collected from patients with PD-B (n = 34) or -C (n = 27) and healthy controls (HCs) (n = 28). Salivary and plasma levels of total C3, C3c, and C3dg were quantified using sandwich enzyme-linked immunosorbent assay (ELISA). Results: Salivary levels of total C3 and C3dg were elevated in PD-B and PD-C patients compared to HCs (both P |
| Databáze: | OpenAIRE |
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