Up-regulated serum levels of soluble CD25 and soluble CD163 in pediatric patients with SARS-CoV-2

Autor:	Gehan Ahmed, Mostafa, Hanan Mohamed, Ibrahim, Abeer, Al Sayed Shehab, Yasmin Gamal El, Gendy, Dina Medhat Mohamed, Aly, Ghada Abdel Haleem, Shousha
Rok vydání:	2022
Předmět:	SARS-CoV-2 fungi Interleukin-2 Receptor alpha Subunit Antigens Differentiation Myelomonocytic COVID-19 Infant Receptors Cell Surface Lymphohistiocytosis Hemophagocytic Systemic Inflammatory Response Syndrome Antigens CD Pediatrics Perinatology and Child Health Humans Child Cytokine Release Syndrome Biomarkers
Zdroj:	European Journal of Pediatrics. 181:2299-2309
ISSN:	1432-1076
DOI:	10.1007/s00431-022-04398-8
Popis:	Similar to hemophagocytic lymphohistiocytosis (HLH), some patients with SARS-CoV-2 have cytokine storm. Serum soluble interleukin-2 receptor (sCD25) and soluble CD163 (sCD163) are potential diagnostic biomarkers for HLH that help in guiding its treatment. This study was the first to investigate serum sCD25 and sCD163 levels in SARS-CoV-2. Serum sCD25 and sCD163 were measured by ELISA in 29 patients with SARS-CoV-2, aged between 2 months and 16 years (13 had COVID-19 and 16 had multisystem inflammatory syndrome in children (MIS-C)), in comparison to 30 age- and sex-matched healthy control children and 10 patients with HLH. Levels of these markers were re-measured in 21 patients with SARS-CoV-2 who were followed up 3 months after recovery. Patients with SARS-CoV-2 had significantly higher serum sCD25 and sCD163 than healthy control children (P P P Conclusion: Serum sCD25 and sCD163 levels were up-regulated in SARS-CoV-2 patients. Serum sCD25 was a good differentiating marker between SARS-CoV-2 and HLH. This initial report requires further studies, on large scales, to investigate the relationship between SARS-CoV-2 and both sCD25 and sCD163, including the disease severity and outcome. The therapeutic role of sCD25 and sCD163 antagonists should also be studied in SARS-CoV-2 patients. What is Known:• Similar to hemophagocytic lymphohistiocytosis (HLH), some patients with COVID-19 have cytokine storm due to excessive pro-inflammatory host response.• Serum soluble interleukin-2 receptor (sCD25) and soluble CD163 (sCD163) are potential diagnostic biomarkers for HLH. Monitoring of serum sCD25 and sCD163 levels can also help in guiding the treatment. What is New:• Serum sCD25 and sCD163 levels are up-regulated in patients with COVID-19, including patients presenting with multisystem inflammatory syndrome in children (MIS-C).• Serum sCD25 is a good differentiating marker between SARS-CoV-2 and HLH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c7683a130bdfa9df5485a9951e028 https://doi.org/10.1007/s00431-022-04398-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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