Galanin of the homologous species inhibits insulin secretion in the rat and in the pig
| Autor: | H. Mårtensson, Gerald J. Taborsky, Stefan Lindskog, Ar'Rajab A, Bo Ahrén, B. E. Dunning |
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| Rok vydání: | 1990 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Swine Physiology medicine.medical_treatment Neuropeptide Galanin In Vitro Techniques Biology Islets of Langerhans Species Specificity In vivo Internal medicine Insulin Secretion Mole medicine Animals Insulin Pancreatic hormone geography geography.geographical_feature_category Neuropeptides digestive oral and skin physiology Rats Inbred Strains Islet In vitro Rats Glucose Endocrinology nervous system Peptides hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Physiologica Scandinavica. 139:591-596 |
| ISSN: | 1365-201X 0001-6772 |
| DOI: | 10.1111/j.1748-1716.1990.tb08963.x |
| Popis: | It is known that pig galanin inhibits insulin secretion in dogs, rats and mice. The present study examined whether species-specific, homologous, galanin inhibits insulin secretion. Thus, the effects of rat galanin were examined in the rat, and the effects of pig galanin were examined in the pig, both in vivo and in vitro. In conscious rats, synthetic rat galanin (2 nmol kg-1) abolished the glucose- (0.56 mmol kg-1) induced increase in plasma insulin levels. In vitro, rat galanin (10(-9) to 10(-6) mol l-1) inhibited glucose- (8.3 mmol l-1) stimulated insulin release from isolated rat islets. In anaesthetized pigs, 15 min infusion of synthetic pig galanin (207 pmol min-1) into the pancreatic artery decreased the insulin output with a subsequent recovery. In vitro, pig galanin (10(-6) mol l-1) inhibited glucose- (8.3 mmol l-1) stimulated insulin release from isolated pig islets. We conclude that homologous galanin inhibits insulin secretion in both the rat and the pig. |
| Databáze: | OpenAIRE |
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