Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan
Autor: | Yen-Hsien Lee, Li-Hsiou Chen, Chia-Wen Tsai, Kuo-Liang Chiu, Wen-Shin Chang, Da Tian Bau, Chia-Hsiang Li, Te Chun Hsia, Yi-Cheng Shen, Te Chun Shen |
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Rok vydání: | 2020 |
Předmět: |
Cancer Research
medicine.medical_specialty MMP2 Genotype Taiwan Gastroenterology Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Gene Frequency Internal medicine Medicine Humans Genetic Predisposition to Disease Allele Promoter Regions Genetic Asthma Pharmacology business.industry Healthy subjects Odds ratio medicine.disease Confidence interval Case-Control Studies Matrix Metalloproteinase 2 business Research Article |
Zdroj: | In Vivo |
ISSN: | 1791-7549 |
Popis: | Background/aim Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese. Materials and methods One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes. Results CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053. Conclusion The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan. |
Databáze: | OpenAIRE |
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