Perinatal and post-weaning exposure to an obesogenic diet promotes greater expression of nuclear factor-κB and tumor necrosis factor-α in white adipose tissue and hypothalamus of adult rats
| Autor: | Jean Nunes dos Santos, Gabriela dos Santos Perez, L. S. Santos, Ingrid de Oliveira Ribeiro, Mariane dos Santos Gonçalves, Rhowena Jane Barbosa de Matos, Jairza Maria Barreto Medeiros, G. S. Cordeiro |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Offspring Adipose Tissue White Hypothalamus Medicine (miscellaneous) Weaning White adipose tissue Biology Diet High-Fat 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Internal medicine Lactation Adipocyte medicine Animals Rats Wistar 030109 nutrition & dietetics Nutrition and Dietetics Tumor Necrosis Factor-alpha General Neuroscience Body Weight NF-kappa B General Medicine medicine.disease Rats medicine.anatomical_structure Endocrinology Adipose Tissue chemistry Female Tumor necrosis factor alpha 030217 neurology & neurosurgery |
| Zdroj: | Nutritional Neuroscience. 25:502-510 |
| ISSN: | 1476-8305 1028-415X |
| Popis: | Aim: To analyze the effects of exposure to a high-fat diet during the perinatal period and after weaning on white adipose tissue accumulation and gene expression of TNF- α and NF- κB.Method: Wistar female rats were fed with high-fat (H) or control (C) diet during pregnancy and lactation. The offspring were allocated into four groups: Control Control (CC), offspring of mothers GC, fed a control diet after weaning; Control High-fat (CH), offspring of mothers GC, fed a hight-fat diet after weaning; High-fat Control (HC), offspring of mothers GH, fed with control diet after weaning; and High-fat High-fat (HH), offspring of mothers GH, fed a H diet after weaning.Results: HH and HC groups showed increased body weight compared to CC group and increases in caloric intake, larger amount of white adipose tissue and adipocyte size compared to CC and CH groups. The HH and CH groups showed higher NF-kB expression in white adipose tissue compared to the CC and HC groups, and the HH group also showed higher TNF- α expression. In the hypothalamus, the HH and HC groups exhibited higher TNF- α expression compared to the CC and CH groups.Conclusion: Perinatal and post-weaning exposure to the high-fat diet increases the amount of white adipose tissue, adipocyte size, and expression of the inflammatory genes TNF-α and NF-kB. |
| Databáze: | OpenAIRE |
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