Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets
| Autor: | Corinna N. Ross, Adam B. Salmon, Aubrey Sills, Brian D. DeRosa, Joselyn M. Artavia |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0106 biological sciences Aging Rodent Physiology Inflammation 010603 evolutionary biology 01 natural sciences Article Blood cell Sex Factors biology.animal medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Dosing Mechanistic target of rapamycin Ecology Evolution Behavior and Systematics PI3K/AKT/mTOR pathway Sirolimus Blood Cells biology business.industry TOR Serine-Threonine Kinases 05 social sciences Callithrix biology.organism_classification medicine.anatomical_structure Cohort biology.protein Female Animal Science and Zoology medicine.symptom business |
| Zdroj: | American Journal of Primatology. 81:e22927 |
| ISSN: | 0275-2565 |
| DOI: | 10.1002/ajp.22927 |
| Popis: | Interventions to extend lifespan and improve health with increasing age would have significant impact on a growing aged population. There are now several pharmaceutical interventions that extend lifespan in laboratory rodent models with rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) being the most well studied. In this study, we report on the hematological effects on a cohort of middle-aged common marmosets (Callithrix jacchus) that were enrolled in a study to test the effects of daily rapamycin treatment on aging in this species. In addition, we assessed whether sex was a significant factor in either baseline assessment or as an interaction with rapamycin treatment. Among our cohort at baseline, we found few differences in either basic morphology or hematological markers of blood cell counts, metabolism or inflammation between male and female marmosets. After dosing with rapamycin, surprisingly we found trough blood concentrations of rapamycin were significantly lower in female compared to male marmosets. Despite this pharmacological difference, both sexes had only minor changes in cellular blood counts after 9 months of rapamycin. These data then suggest that the potential clinical hematological side effects of rapamycin are not likely outcomes of long-term rapamycin in relatively healthy, middle-aged marmosets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text