PGE restores the immune response in chemotherapy-treated, tumor-bearing mice
| Autor: | Peter Leport, Bernard M. Jaffe, Cristine Rinaldi, M.Gabriella Santoro, Cartesio Favalli |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Prostaglandins E
Synthetic medicine.medical_specialty Vincristine Cellular immunity medicine.medical_treatment Biology General Biochemistry Genetics and Molecular Biology Mice chemistry.chemical_compound Immune system 16 16-Dimethylprostaglandin E2 Internal medicine medicine Animals Mechlorethamine General Pharmacology Toxicology and Pharmaceutics Melanoma Immunosuppression Therapy Immunity Cellular Chemotherapy Immunosuppression General Medicine Nitrogen mustard Mice Inbred C57BL Endocrinology chemistry Doxorubicin Delayed hypersensitivity Antibody Formation Humoral immunity Drug Therapy Combination medicine.drug |
| Zdroj: | Life Sciences. 30:1219-1223 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(82)90666-x |
| Popis: | Two hundred seventy-one B-16 melanoma-bearing mice were randomized and treated for 4 days with either control diluent, 10 μg of 16, 16-dimethyl-PGE2-methyl-ester (di-M-PGE2), chemotherapy, or chemotherapy plus di-M-PGE2. The chemotherapeutic regimens included adriamycin (7.5 mg/kg), 5-fluorouracil (250 mg/kg), nitrogen mustard (5 mg/kg), and vincristine (0.5 mg/kg). The number of plaque-forming cells and hemagglutinin titers in response to sheep erythrocytes were used as measures of humoral immunity while cellular immunity was assessed by evaluation of delayed hypersensitivity. As we previously reported, the presence of subcutaneous B-16 tumors induced substantial immunosuppression and this suppression was reversed by treatment with di-M-PGE2. Treatment with all four chemotherapeutic agents induced profound immunosuppression. Similarly, the addition of di-M-PGE2 to the chemotherapy protocols resulted in significant augmentation of cellular and humoral immunity. |
| Databáze: | OpenAIRE |
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