Grossly Abnormal Ventilation/Perfusion SPECT Study in Idiopathic Pulmonary Arterial Hypertension Without Thromboembolism
| Autor: | Alan W. Bates, Benjamin E. Schreiber, John G Coghlan, Margaret L. Hall, Jamanda Haddock, Kenneth Chan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac Catheterization medicine.medical_specialty Computed Tomography Angiography Hypertension Pulmonary Pulmonary Artery 030204 cardiovascular system & hematology Ventilation/perfusion ratio Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Ventilation-Perfusion Ratio medicine Pulmonary angiography Humans Pulmonary Wedge Pressure 030212 general & internal medicine Lung Asthma Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Idiopathic Pulmonary Arterial Hypertension medicine.disease Pulmonary hypertension Breathing Cardiology Female Pulmonary Embolism Cardiology and Cardiovascular Medicine business Perfusion Emission computed tomography |
| Zdroj: | Heart, Lung and Circulation. 27:e101-e104 |
| ISSN: | 1443-9506 |
| DOI: | 10.1016/j.hlc.2018.01.001 |
| Popis: | Pulmonary hypertension is a serious condition with multiple underlying aetiologies which require different treatment strategies. We present a case of severe idiopathic pulmonary arterial hypertension in a 20-year-old patient with ongoing breathlessness. She was initially diagnosed with asthma and panic attacks in community care. As the symptoms became progressively worse, she was referred for pulmonary hypertension clinic assessment. Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) showed grossly abnormal perfusion defects which were mismatched to the ventilation scan, suggestive of chronic thromboembolic disease. However, corroborating computed tomographic (CT) pulmonary angiogram and invasive pulmonary angiography showed no thromboembolic disease. Histological examination of the pulmonary arteries post-mortem showed changes consistent with idiopathic pulmonary arterial hypertension. This case highlighted the clinical challenges in interpreting the investigation results and phenotyping pulmonary hypertension. V/Q SPECT might have a role in visualising the extent of vasculopathies in pulmonary arterial hypertension. |
| Databáze: | OpenAIRE |
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