Neglected, Drug-Induced Platinum Accumulation Causes Immune Toxicity
| Autor: | Xuchun Huang, Yuling Zhang, Yi Jiang, Ling Fang, Zheng Jieting |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Anemia medicine.medical_treatment chemistry.chemical_element Pharmacology 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) platinum Original Research Cisplatin Chemotherapy Chemistry lcsh:RM1-950 toxicity medicine.disease Oxaliplatin drug-induced lcsh:Therapeutics. Pharmacology 030104 developmental biology 030220 oncology & carcinogenesis Toxicity Hemoglobin immune Platinum accumulation medicine.drug Blood sampling |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| ISSN: | 1663-9812 |
| Popis: | Previous studies only focused on different adverse reactions caused by various platinum drugs, but not on common immunotoxicity caused by the accumulation of elemental platinum. Here, we determined the serum platinum concentrations of cancer patients after a metabolism period of platinum drug chemotherapy, in addition to hematological indices and subsequent immune-related adverse reactions, then analyzed the correlations between platinum accumulation, immune cell levels, and immune-toxicity. We chose the day before the next round of chemotherapy as the specified time point for blood sampling. Samples were collected at five time points, separately in oxaliplatin and cisplatin groups. The median serum platinum concentrations in all patients was 294.8 (205.6, 440.3) μg/L, and was approximately two-fold greater in the cisplatin group than in the oxaliplatin group (429.3 vs. 211.7 μg/L). The platinum level of both groups peaked at the third time point, with the average of females being higher than males (383.9 vs. 266.5 μg/L), and was positively correlated with leukocyte and platelet counts, but negatively correlated with erythrocyte counts and concentration of hemoglobin. The risks of anemia and adverse reactions were individually increased by 0.002- and 0.007-fold for every μg/L increase of platinum concentration. To our knowledge, this is the first study on the relationship between platinum accumulation, immune cell levels and toxicity, showing that drug-induced platinum accumulation may interfere with immune cells and thus increase the risk of toxicity. |
| Databáze: | OpenAIRE |
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