Influence of hypercholesterolemia and acute graft rejection on chronic nephropathy development in renal transplant recipients
| Autor: | Przemysław Szyber, Marian Klinger, Mirosław Banasik, Andrzej T. Dorobisz, Maria Boratyńska, Ewa Watorek |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Time Factors Hypercholesterolemia Population Azathioprine Gastroenterology Nephropathy chemistry.chemical_compound Postoperative Complications Recurrence Internal medicine medicine Humans education Retrospective Studies Transplantation Creatinine education.field_of_study business.industry Incidence Patient Selection Retrospective cohort study medicine.disease Kidney Transplantation Surgery Cholesterol surgical procedures operative chemistry Concomitant Chronic Disease business Follow-Up Studies medicine.drug Kidney disease |
| Zdroj: | Transplantation Proceedings. 35:2209-2212 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/s0041-1345(03)00773-5 |
| Popis: | Graft endothelial lesions resulting from acute rejection may be sustained by concomitant hypercholesterolemia, thus increasing the risk of chronic graft failure. The present study was undertaken to examine the influence of hypercholesterolemia and acute graft rejection (AGR) episodes on graft function and graft loss due to chronic nephropathy. A cohort of 336 patients transplanted between 1993 and 2000 having graft function at 12 months after transplantation were examined. Immunosuppressive therapy consisted of CsA, azathioprine, and corticosteroids in 90% with 10% of patients receiving mycophenolate mofetil in place of azathioprine. During the first year after transplantation, AGR occurred in 134 (39.8%) and hypercholesterolemia (6.2 mmol/L) in 132 (39.2%) of patients. The population was divided into four groups according to AGR occurrence and cholesterol concentrations during the first year after transplantation for analysis of serum creatinine concentrations and graft loss at 5 years of follow-up. Patients with AGR irrespective of cholesterol levels displayed significantly higher creatinine concentrations. Graft loss in these patients increased over twofold compared to the remaining groups. Patients without hypercholesterolemia and AGR showed normal creatinine concentrations and low graft loss rates during 5 years of follow-up. |
| Databáze: | OpenAIRE |
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