Predictive factors for osteoradionecrosis of the jaws: A retrospective study
| Autor: | Gareth Davies, Hans Prakash Sathasivam, Nicholas M. Boyd |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Osteoradionecrosis Risk Assessment Severity of Illness Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Aged Proportional Hazards Models Retrospective Studies Squamous Cell Carcinoma of Head and Neck business.industry Proportional hazards model Incidence (epidemiology) Head and neck cancer Radiotherapy Dosage Retrospective cohort study 030206 dentistry Middle Aged medicine.disease Head and neck squamous-cell carcinoma Surgery Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Predictive value of tests Multivariate Analysis Carcinoma Squamous Cell Female business Jaw Diseases Follow-Up Studies Cohort study |
| Zdroj: | Head & Neck. 40:46-54 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.24907 |
| Popis: | Background Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. Methods A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors. Results Fifty-nine patients had ORNJ. Statistical analysis using Cox regression analysis identified several statistically significant variables: dentoalveolar surgery; peri-resective surgery of the jaw; continued tobacco usage after radiotherapy, diabetes mellitus type 2 (DM2); and total radiation dose. Conclusion Patients at greater risk of developing ORNJ can be identified and measures can be instituted to reduce its incidence and expedite management when it does occur. |
| Databáze: | OpenAIRE |
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