Comparison of a pediatric-inspired treatment protocol versus standard-intensity chemotherapy for young adults with standard-risk BCR-ABL negative acute lymphoblastic leukemia
| Autor: | David Sanford, Thomas J. Nevill, Alina S. Gerrie, Raewyn Broady, Kevin W. Song, Yasser Abou Mourad, Michael L. Barnett, Heather J. Sutherland, Donna L. Forrest, Maryse M. Power, Cynthia L. Toze, Sujaatha Narayanan, Stephen H. Nantel, David Simon Kliman, Donna E. Hogge |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Asparaginase Adolescent medicine.medical_treatment Maintenance Chemotherapy Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Young adult Child Chemotherapy ABL business.industry Remission Induction Age Factors Infant Newborn breakpoint cluster region Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Surgery Intensity (physics) Consolidation Chemotherapy Treatment Outcome Oncology chemistry Child Preschool 030220 oncology & carcinogenesis Toxicity Cohort Female business 030215 immunology |
| Zdroj: | Leukemia & Lymphoma. 58:909-915 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428194.2016.1222376 |
| Popis: | We investigated the utility of a pediatric-inspired protocol in adults aged 18–40 years with standard-risk BCR-ABL negative acute lymphoblastic leukemia (ALL). Retrospective outcomes of 25 patients treated with a pediatric protocol between 2008 and 2014 were compared with 22 similarly aged patients treated with an adult protocol between 2003 and 2008. Twenty-five (100%) and 19 (86%) patients achieved complete remission, respectively. At median follow-up of 36.8 months, 3-year event-free survival was increased in patients on the pediatric protocol at 80% versus 45% (p = .019). There was a trend toward improved overall survival at 80% versus 59% (p = .12). Treatment-related toxicity was not increased despite the increased treatment intensity. Patients with BCR and/or ABL copy number variation demonstrated comparatively poorer outcomes in both cohorts. In our experience with this cohort of patients, pediatric-based protocols are safe and effective, justifying their use in younger adults with ALL. |
| Databáze: | OpenAIRE |
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